The genetic studies of Parsis of Pakistan show sharp contrast between genetic data obtained from mitochondrial DNA (mtDNA) and Y-chromosome DNA (Y-DNA), different from most populations. Historical records suggests that they had moved from Iran to Gujarat, India and then to Mumbai and Karachi, Pakistan. According to Y-DNA, they resemble the Iranian population, which supports historical records. When the mtDNA pool is compared to Iranians and Gujaratis (their putative parental populations), it contrasted Y-DNA data. About 60% of their maternal gene pool originates from South Asian haplogroups, which is just 7% in Iranians. Parsis have a high frequency of haplogroup M (55%), similar to Indians, which is just 1.7% in combined Iranian sample. The studies suggest sharp contrast between the maternal and paternal component of Parsis. Due to high diversity in Y-DNA and mtDNA lineages, the strong drift effect is unlikely even though they had a small population. The studies suggest a male-mediated migration of Parsi ancestors from Iran to Gujarat where they admixed with the local female population during initial settlements, which ultimately resulted in loss of Iranian mtDNA.